Download PDF by Hugo O. Villar (Eds.): Advances in Computational Biology

By Hugo O. Villar (Eds.)

The second one quantity in a chain which goals to target advances in computational biology. This quantity discusses such subject matters as: statistical research of protein sequences; development in large-scale series research; and the structure of loops in proteins

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In contrast, the strong fluctuations near the pure lipid limit will strongly influence the manifestations of the lipid-protein interactions. C. , 1993; Huang and Feigenson, 1993). Figure 8 gives examples of lateral organization obtained from computer simulations near the main transition in a pure DPPC lipid bilayer and for a binary DMPC-DSPC lipid mixture in the fluid phase. The two frames illustrate the effect of density (area) fluctuations and compositional fluctuations, respectively. The densityfluctuationsin Figure 8(a) manifest themselves in the formation of domains or clusters of correlated lipids of a structure and a density different from that of the bulk equilibrium lipid matrix.

17). 36 Computation of Lipid-Protein Interactions 37 impossible to distinguish between a weak first-order transition and a pseudotransition dominated by very strong fluctuations. The numerical work presented here supports the hypothesis that lipid bilayers exhibit pseudocritical behavior and are close to a critical point (Biltonen, 1990; Mouritsen, 1991). B. Two-Component Lipid Bilayers The possible absence of a phase transition in one-component lipid bilayers poses some intriguing problems as to the existence of phase equilibria in lipid bilayers incorporated with other species, such as other lipids, cholesterol, or proteins.

F(L) is shown as a function of system size for the three values of F^ corresponding to Figures 4(a-c). Figure 5 shows that Air(L) decreases with increasing L for F^ = 3 x 10~^^erg/A, implying the absence of a transition, and increases with increasing L for F^ = 5 x 10~^^erg/A, implying the occurrence of a first-order phase transition. For F^ = 4 x 10"^^erg/A, the height of the barrier does not depend on system size to within calculational error, indicating that the transition for this parameter value is almost at a critical point.

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